Keyword Analysis & Research: mpd disorder platelet
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5156 - Gene ResultPDGFRA platelet derived growth factor ...
Apr 04, 2021 · This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and …
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Myeloproliferative neoplasm - Wikipedia
Myeloproliferative neoplasms (MPNs) are a group of rare blood cancers in which excess red blood cells, white blood cells or platelets are produced in the bone marrow. Myelo refers to the bone marrow, proliferative describes the rapid growth of blood cells and neoplasm describes that growth as abnormal and uncontrolled.. The overproduction of blood cells is often associated with a somatic ...
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Erythrocytosis - an overview | ScienceDirect Topics
Erythrocytosis (polycythemia) is characterized by an increase in RBC mass and can be either primary, as the result of a myeloproliferative disorder (MPD) such as PV, or secondary, as a result of defective congenital hemoglobin, chronic hypoxia related to a respiratory or cardiac disorder, ectopic (e.g. erythropoietin producing malignancy) or ...
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Imatinib mesylate | C30H35N7O4S - PubChem
Imatinib Mesylate is the mesylate salt of imatinib, a tyrosine kinase inhibitor with antineoplastic activity. Imatinib binds to an intracellular pocket located within tyrosine kinases (TK), thereby inhibiting ATP binding and preventing phosphorylation and the subsequent activation of growth receptors and their downstream signal transduction pathways. . This agent inhibits TK encoded by the bcr ...
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OMIM Entry - # 163950 - NOONAN SYNDROME 1; NS1
The disorder now known as Noonan syndrome bears similarities to the disorder described by Turner (1938) and shown by Ford et al. (1959) to have its basis in a 45,X chromosomal aberration called Turner syndrome, Ullrich-Turner syndrome (Wiedemann and Glatzl, 1991), or monosomy X. . Migeon and Whitehouse (1967) described 2 families, each with 2 sibs with somatic features of the Turner phenotype.
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