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Reference ID: 3989896
Hypersensitivity to ticagrelor or an. y component of the product (4.3)----- WARNINGS AND PRECAUTIONS ----- Dyspnea was reported more frequently with BRILINTA than with control agents in clinical trials. Dyspnea resulting from BRILINTA is self-limiting. (5.3) Severe Hepatic Im. pair. ment: Likely increase in exposure to ticagrelor…
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BRILINTA 5.2) Initial U.S. Approval: 2011
BRILINTA (ticagrelor) 60 mg is supplied as a round, biconvex, pink, film-coated tablet marked with “60” above “T” on one side. 2 Reference ID: 4232366 . 4 CONTRAINDICATIONS . 4.1 History of …
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Ticagrelor (BRILINTA Drug Monograph Addendum
Ticagrelor Compared to Placebo on a Background of Aspirin-Thrombolysis in Myocardial Infarction 54) was a randomized, double-blind, placebo-controlled, multinational, industry sponsored trial that evaluated the efficacy and safety of two doses of ticagrelor …
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The new england journal medicine
Ticagrelor is an oral, reversible, direct-acting inhibitor of the adenosine diphos - phate receptor P2Y12 that has a more rapid onset and more pronounced platelet inhibition than clopidogrel.
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US-47114 ---------------------------- DOSAGE AND ...
ticagrelor) 60 mg is supplied as a round, biconvex, pink, film-coatedtablet marked with “60” above “T” on one side. 4: CONTRAINDICATIONS 4.1 : History of Intracranial Hemorrhage: BRILINTA: is …
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[PDF] Ticagrelor: the evidence for its clinical potential ...
Introduction: Ticagrelor, the first direct-acting, reversibly binding oral P2Y12 receptor antagonist, appears to have a favorable efficacy and safety profile. Aims: To update the evidence and provide an overview of the available data on ticagrelor…
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What kind of tablet is 90 mg of ticagrelor?
(ticagrelor) 90 mg is supplied as a round, biconvex, yellow, film-coated tablet marked with a “90” above “T” on one side. BRILINTA (. ticagrelor) 60 mg is supplied as a round, biconvex, pink, film-coated tablet marked with “60” above “T” on one side.
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What's the difference between clopidogrel and ticagrelor?
Ticagrelor is an oral, reversible, direct-acting inhibitor of the adenosine diphosphate receptor P2Y12 that has a more rapid onset and more pronounced platelet inhibition than clopidogrel.
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Why is ticagrelor used in patients with severe hepatic impairment?
Avoid the use of ticagrelor in patients with severe hepatic impairment because it is metabolized by the liver and impaired hepatic function can increase risks for bleeding and other adverse events. In addition, severe hepatic impairment increases the risk of bleeding because of reduced synthesis of coagulation proteins.
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Are there any side effects of discontinuing ticagrelor?
Discontinuation of ticagrelor increases the risk of myocardial infarction, stent thrombosis, and death. The safety and efficacy of ticagrelor in neonates, infants, children, or adolescents have not been established.
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