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Ticagrelor Uses, Side Effects & Warnings - Drugs.com
Jan 22, 2021 · Ticagrelor keeps your blood from coagulating (clotting) and can make it easier for you to bleed, even from a minor injury. Contact your doctor or seek emergency medical attention if you have …
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BRILINTA® (ticagrelor) tablets - Treatment | ACS | Acute ...
BRILINTA® (ticagrelor) is an oral prescription indicated for treatment of acute ischemic stroke, coronary artery disease and acute coronary syndrome.
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Ticagrelor-induced thrombotic thrombocytopenic purpura: A ...
Rationale: Ticagrelor, a new type of P2Y12 receptor antagonist, has been highly recommended to be used in acute coronary syndrome by the latest guideline, but its side effects are not well-known. We seek to illustrate a potential fatal condition, thrombotic thrombocytopenic purpura (TTP), caused by ticagrelor. Patient concerns: An 87-year-old man who had been prescribed with ticagrelor …
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Ticagrelor - Wikipedia
Like the thienopyridines prasugrel, clopidogrel and ticlopidine, ticagrelor blocks adenosine diphosphate (ADP) receptors of subtype P2Y12. In contrast to the other antiplatelet drugs, ticagrelor has a binding site different from ADP, making it an allosteric antagonist, and the blockage is reversible. Moreover, the drug does not need hepatic activation, which might work better for patients with genetic variants regarding the enzyme CYP2C19(although it is not certain whether clopidogrel is significantly influenced by such varia…
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What's the generic name for the drug ticagrelor?
Generic name: ticagrelor (tye KA grel or) Brand name: Brilinta (ticagrelor), Brilinta Dosage forms: oral tablet (60 mg; 90 mg) Drug class: Platelet aggregation inhibitors
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Are there any side effects to taking ticagrelor?
Stopping ticagrelor may increase your risk of a heart attack or stroke. You should not use ticagrelor if you are allergic to it, or if you have: a history of bleeding in the brain (such as from a head injury ). asthma, COPD (chronic obstructive pulmonary disorder) or other breathing problem.
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How is ticagrelor used in the treatment of heart attack?
Ticagrelor is used for the prevention of thrombotic events (for example stroke or heart attack) in different categories of patients.
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How is the bioavailability of ticagrelor determined?
Pharmacokinetics. Ticagrelor is absorbed quickly from the gut, the bioavailability being 36%, and reaches its peak concentration after about 1.5 hours. The main metabolite, AR-C124910XX, is formed quickly via CYP3A4 by de-hydroxyethylation at position 5 of the cyclopentane ring. It peaks after about 2.5 hours.
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