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Ticagrelor in Patients with Stable Coronary Disease and ...
Sep 01, 2019 · Ticagrelor in Patients with Stable CAD and Diabetes Patients with stable coronary artery disease and diabetes were randomly assigned to receive either ticagrelor plus aspirin or placebo plus...
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Coronary Artery Disease (CAD) | BRILINTA® (ticagrelor ...
BRILINTA® (ticagrelor) is indicated for treatment in patients with high-risk coronary artery disease (CAD) without history of MI or stroke.
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Coronary Artery Disease (CAD) | BRILINTA® (ticagrelor) tablets
Coronary artery disease (CAD) is the most common form of heart disease in the United States. When people have CAD, plaque has built up in their heart's arteries …
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Ticagrelor Risky in Diabetic Patients With Stable CAD ...
Sep 01, 2019 · Unless the patient has a high risk of ischemic events, and low propensity for bleeding, use of ticagrelor in stable CAD patients with diabetes carries an unfavorable risk-benefit profile, the researchers said.
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FDA Extends Ticagrelor Indication to High-Risk CAD Primary ...
Jun 01, 2020 · Ticagrelor (Brilinta) can be used for primary prevention of MI or stroke in high-risk patients with coronary artery disease, according to a new indication granted by the US Food and Drug Administration today.
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Ticagrelor Versus Clopidogrel in Patients With Symptomatic ...
The EUCLID trial randomized 13,885 patients with PAD to antithrombotic monotherapy with ticagrelor or clopidogrel. CAD was defined as prior myocardial infarction (MI), percutaneous coronary intervention (PCI), or coronary artery bypass graft (CABG) surgery. Median follow-up was 30 months.
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THEMIS-PAD: Ticagrelor Reduces Risk of Limb Events in ...
Aug 29, 2020 · In patients with coronary artery disease (CAD) and type 2 diabetes (T2D), the risk of limb ischemic events was about 10-times higher in patients with, vs. without, peripheral artery (PAD) enrolled in the THEMIS study – and they had a greater absolute benefit from the reduction in limb events gained with ticagrelor.
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BRILINTA® (ticagrelor) tablets - Acute Ischemic Stroke | CAD
BRILINTA® (ticagrelor) is an oral prescription indicated for treatment of acute ischemic stroke, coronary artery disease and acute coronary syndrome.
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Who are high risk patients for ticagrelor use?
Wilhelm Ridderstråle, M.D., Drs. Steg and Bhatt contributed equally to this article. Patients with stable coronary artery disease and diabetes mellitus who have not had a myocardial infarction or stroke are at high risk for cardiovascular events. Whether adding ticagrelor to aspirin improves outcomes in this population is unclear.
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When to take clopidogrel vs.ticagrelor in CABG?
In patients undergoing CABG, it was recommended that the study drug be withheld — in the clopidogrel group, for 5 days, and in the ticagrelor group, for 24 to 72 hours. All patients received acetylsalicylic acid (aspirin) at a dose of 75 to 100 mg daily unless they could not tolerate the drug.
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What is the annual event rate for ticagrelor?
The primary efficacy outcome was tested at a two-sided 4.96% significance level after adjustment for an interim efficacy analysis with a familywise error rate of 5%. We estimated that the annual event rate in the placebo group would be 2.5%.
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How does ticagrelor reduce risk of limb events?
The very high risk of limb events in patients with PAD, on top of CAD and T2D, and reductions with ticagrelor of about 50% for major adverse limb events and 20% for peripheral revascularization suggests long-term benefit with the drug for preventing cardiovascular and limb events, researchers said.
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