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A comprehensive review of SHP2 and its role in cancer - PubMed
https://pubmed.ncbi.nlm.nih.gov/36066752/
WebSHP2 modulates diverse cell signaling events that control metabolism, cell growth, differentiation, cell migration, transcription and oncogenic transformation. It interacts with diverse molecules in the cell, and regulates key signaling events including RAS/ERK, PI3K/AKT, JAK/STAT and PD-1 pathways downstream of several receptor tyrosine ...
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SHP2 is a multifunctional therapeutic target in drug resistant
https://www.nature.com/articles/s41388-020-01488-5
WebOct 8, 2020 · SH2 containing protein tyrosine phosphatase-2 (SHP2) is an oncogenic phosphatase known to facilitate growth and survival signaling downstream of numerous receptor inputs. Herein, we...
DA: 99 PA: 54 MOZ Rank: 47
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Recent Advances of SHP2 Inhibitors in Cancer Therapy: Current …
https://pubmed.ncbi.nlm.nih.gov/32460492/
WebOct 22, 2020 · SHP2 (Src homology-2 domain-containing protein tyrosine phosphatase-2) is a non-receptor protein tyrosine phosphatase that removes tyrosine phosphorylation. Functionally, SHP2 serves as an important hub to connect several intracellular oncogenic signaling pathways, such as Jak/STAT, PI3K/AKT, RAS/Ra ….
DA: 22 PA: 78 MOZ Rank: 99
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A comprehensive review of SHP2 and its role in cancer
https://link.springer.com/article/10.1007/s13402-022-00698-1
WebSep 6, 2022 · SHP2 is now considered as a compelling anticancer drug target and several classes of SHP2 inhibitors with different mode of action are developed with some already in clinical trial phases. Moreover, novel SHP2 substrates and functions are rapidly growing both in cell and cancer.
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SHP2 Inhibitors for Treating Cancer - National Cancer Institute
https://www.cancer.gov/research/key-initiatives/ras/news-events/dialogue-blog/2021/neel-shp2-inhibitors
WebApr 15, 2021 · SHP2, a ubiquitously expressed non-receptor protein-tyrosine phosphatase encoded by the PTPN11 gene, lies downstream of almost all RTKs and is required for RTK-evoked RAS activation [12]. These features suggested that SHP2 inhibitors (SHP2i) might be attractive candidates for combination therapy to enhance MEK inhibitor …
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Targeting SHP2 for Cancer Treatment: Advances and Prospects
https://link.springer.com/referenceworkentry/10.1007/978-3-030-80962-1_256-1
WebJan 4, 2023 · Dephosphorylase. SHP2. Drug discovery. PROTAC. Drug resistance. Introduction. Src homology region 2-containing protein tyrosine phosphatase 2 (SHP2), also named as PTP1D or PTP-2C, is a cytoplasmic non-receptor protein tyrosine phosphatase (PTP) encoded by the proto-oncogene PTPN11.
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SHP2 blockade enhances anti-tumor immunity via tumor cell
https://www.nature.com/articles/s41598-021-80999-x
WebJan 14, 2021 · SHP2 is a ubiquitous tyrosine phosphatase involved in regulating both tumor and immune cell signaling. In this study, we discovered a novel immune modulatory function of SHP2. Targeting this...
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Allosteric inhibition of SHP2 phosphatase inhibits cancers
https://www.nature.com/articles/nature18621
WebJun 29, 2016 · Here we report the discovery of a highly potent (IC50 = 0.071 μM), selective and orally bioavailable small-molecule SHP2 inhibitor, SHP099, that stabilizes SHP2 in an auto-inhibited...
DA: 85 PA: 89 MOZ Rank: 44
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Recent Advances of SHP2 Inhibitors in Cancer Therapy: Current
https://pubs.acs.org/doi/10.1021/acs.jmedchem.0c00249
WebMay 27, 2020 · SHP2 (Src homology-2 domain-containing protein tyrosine phosphatase-2) is a non-receptor protein tyrosine phosphatase that removes tyrosine phosphorylation. Functionally, SHP2 serves as an important hub to connect several intracellular oncogenic signaling pathways, such as Jak/STAT, PI3K/AKT, RAS/Raf/MAPK, and PD-1/PD-L1 …
DA: 63 PA: 49 MOZ Rank: 49
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Strategies to overcome drug resistance using SHP2 inhibitors
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8727779/
WebMar 28, 2021 · Encoded by PTPN11, the SHP2 (Src homology-2 domain-containing protein tyrosine phosphatase-2) is widely recognized as a carcinogenic phosphatase. As a promising anti-cancer drug target, SHP2 regulates many signaling pathways such as RAS-RAF-ERK, PI3K-AKT and JAK-STAT.
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