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Prodrugs for Amines - PMC - National Center for Biotechnology …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245426/
WebMar 3, 2008 · The purpose of this work is to review the published strategies for the production of prodrugs of amines. The review is divided in two main groups of approaches: those that rely on enzymatic activation and those that take advantage … Author: Ana L. Simplício, John M. Clancy, John F. Gilmer DOI: 10.3390/molecules13030519 Publish Year: 2008 Publication: Molecules. 2008 Mar; 13(3): 519-547.
Author: Ana L. Simplício, John M. Clancy, John F. Gilmer
DOI: 10.3390/molecules13030519
Publish Year: 2008
Publication: Molecules. 2008 Mar; 13(3): 519-547.
DA: 11 PA: 28 MOZ Rank: 10
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Prodrugs of Amines | SpringerLink
https://link.springer.com/chapter/10.1007/978-0-387-49785-3_22
WebProdrugs of Amines. Jeffrey P. Krise & Reza Oliyai. Chapter. 7399 Accesses. 2 Citations. Part of the book series: Biotechnology: Pharmaceutical Aspects ( (PHARMASP,volume …
DA: 10 PA: 9 MOZ Rank: 8
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Prodrugs: design and clinical applications - Nature
https://www.nature.com/articles/nrd2468
WebSome of the most common functional groups that are amenable to prodrug design include carboxylic, hydroxyl, amine, phosphate/phosphonate and carbonyl groups. Prodrugs … Author: Jarkko Rautio, Hanna Kumpulainen, Tycho Heimbach, Reza Oliyai, Dooman Oh, Tomi Järvinen, Jouko Savol... Publish Year: 2008
Author: Jarkko Rautio, Hanna Kumpulainen, Tycho Heimbach, Reza Oliyai, Dooman Oh, Tomi Järvinen, Jouko Savol...
Publish Year: 2008
DA: 3 PA: 77 MOZ Rank: 37
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Newly Developed Prodrugs and Prodrugs in Development; an …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070911/
WebFeb 17, 2020 · In the prodrugs mentioned above, the amine or hydroxyl group in the parent drug was linked to a promoiety such that that the prodrug undergoes an …
DA: 67 PA: 74 MOZ Rank: 39
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Prodrugs for Improved Drug Delivery: Lessons Learned from …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7692606/
WebOct 29, 2020 · The ProTide technology allows nucleotide analog delivery to the cells by masking the monophosphate/monophosphonate hydroxyl groups by an aromatic group …
DA: 1 PA: 89 MOZ Rank: 54
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The expanding role of prodrugs in contemporary drug design and …
https://www.nature.com/articles/nrd.2018.46
WebApr 27, 2018 · 239 Altmetric. Metrics. Abstract. Prodrugs are molecules with little or no pharmacological activity that are converted to the active parent drug in vivo by enzymatic …
DA: 86 PA: 45 MOZ Rank: 44
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Molecules | Free Full-Text | Prodrugs for Amines - MDPI
https://www.mdpi.com/1420-3049/13/3/519
WebThree major themes emerge in amine prodrug chemistry: (i) suppression of ionization in order to promote passive diffusion; (ii) increasing the metabolic stability especially of primary amines and peptides; (iii) tissue targeting, …
DA: 61 PA: 91 MOZ Rank: 78
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Prodrugs: design and clinical applications - Nature
https://www.nature.com/articles/nrd2468.pdf
WebJan 25, 2008 · some of the most common functional groups that are amenable to prodrug design include carboxylic, hydroxyl, amine, phosphate/phosphonate and carbonyl …
DA: 66 PA: 41 MOZ Rank: 81