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Post-Polycythemia Vera Myelofibrosis (PPV-MF) (O…
The Evolving Understanding of Prognosis in Post–Essential ...
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Post-Polycythemia Vera Myelofibrosis (PPV-MF) (Oncology
Post-Polycythemia Vera Myelofibrosis (PPV-MF) is a myeloproliferative blood cancer in which the bone marrow makes too many red blood cells. It may also result in …
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Post-Polycythemia Vera Myelofibrosis (PPV-MF) - Pipeline
Oct 10, 2017 · Post-Polycythemia Vera Myelofibrosis (PPV-MF) is a myeloproliferative blood cancer in which the bone marrow makes too many red blood cells.
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Post-ET and Post-PV Myelofibrosis: Updates on a Distinct
For PPV and PET MF, the new MYSEC-PM is helpful for prediction of survival. JAK2-inhibitors and stem cell transplant are the two critical therapeutic approaches in myelofibrosis. Differences between PMF and SMF substantiate the efforts underway to adequately stratify SMF patients with ad hoc prognostic tools and to use such categorization to evaluate available treatment modalities.
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The Evolving Understanding of Prognosis in Post–Essential
In some patients with essential thrombocytopenia or polycythemia vera, which are relatively benign MPNs, MF develops as a natural evolution of their disease, resulting in post–essential thrombocythemia myelofibrosis (PET-MF) or post–polycythemia vera myelofibrosis (PPV-MF).
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Epidemiology and clinical relevance of mutations in
Transformation to secondary myelofibrosis (MF) occurs as part of the natural history of polycythemia vera (PPV-MF) and essential thrombocythemia (PET-MF). Although primary (PMF) and secondary MF are considered similar diseases and managed similarly, there …
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Exploratory Phase II Study of INC424 Patients With …
Mar 20, 2012 · Patients must be diagnosed with PMF, PPV MF or PET-MF, according to the 2008 revised World Health Organization criteria irrespective of JAK2 mutation status. Patients with PMF requiring therapy must be classified as high risk (3 prognostic factors) OR intermediate risk level 2 (2 prognostic factors, no more), OR intermediate risk level 1 (1 prognostic factor, no more) with an enlarged spleen.
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What Is Post Polycythemia Vera Myelofibrosis?
Jul 27, 2021 · Post polycythemia vera myelofibrosis is a condition in which blood disorder develops due to polycythemia vera.
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Is pet/PPV-MF a distinct clinical entity from primary myelofibrosis?
Presenting with the same clinical features, including debilitating symptoms and signs of bone marrow failure, PET/PPV-MF has traditionally been considered akin to primary myelofibrosis (PMF). However, recent observations that PET/PPV-MF may be a distinct clinical entity from PMF have triggered efforts to improve prognostication in these diseases.
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What is the relevance of hemoglobin and platelet count in PPV-MF?
Passamonti and colleagues 9 reported the relevance of a hemoglobin level less than 10 g/dL, platelet count less than 100 × 10 9 /L, and leukocyte count greater than 30 × 10 9 /L as factors predictive of PPV-MF.
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What is primary myelofibrosis (PMF)?
It may present as primary (ie, arising de novo) myelofibrosis (PMF) or evolve from essential thrombocythemia (ET) or polycythemia vera (PV); these forms are referred as PET-MF and PPV-MF, respectively.
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What does PMF stand for?
Recent findings: Diagnostic criteria of primary myelofibrosis (PMF) have been recently updated from the WHO classification. A clear-cut distinction between pre-fibrotic and overt PMF has been done. Concerning PPV and PET MF, the criteria come from 2008.
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