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5593 - Gene ResultPRKG2 protein kinase cGMP …
PKGII inhibits RhoA activity by binding to this small GTPase and causing phosphorylation at its Ser188 site. PKG II also inhibits the activation of the EGFR caused by diverse ligands of the receptor. These data suggest that increased PKG II activity attenuates bFGFinduced proliferation and migration by inhibiting the MAPK/ERK signaling pathway ...
DA: 70 PA: 39 MOZ Rank: 55
PK-GII - Boeing 777-3U3(ER) - Garuda Indonesia - …
PK-GII / PKGII (Garuda Indonesia (SkyTeam Livery)) - Aircraft info, flight history, flight schedule and flight playback. The world’s most popular flight tracker. Track planes in real-time on our flight tracker map and get up-to-date flight status & airport information.
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Expression of cGMP-dependent protein kinase, PKGIα, …
No significant correlation was found between PKGIα, PKGIβ, and PKGII expression and clinicopathological features. The present study is the first to evaluate the expression level of PKG isoforms PKGIα, PKGIβ, and PKGII in the malignant and benign breast tumors. Reduction in the PKG expression is an important evidence to support the antitumor ...
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Type II cGMP-dependent protein kinase negatively …
Jan 29, 2017 · Wild-type PKGII phosphorylated Raf-1 at Ser-43 in a cGMP-dependent manner, but a PKGII D412A/R415A mutant, which has a low affinity for cGMP, did not. Finally, we found that a phospho-mimic mutant, Raf-1 S43D, suppressed FGF2-induced MAPK pathway. These results suggest that PKGII counters FGF-induced MEK/ERK activation through the ...
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PK-GII | PKGII | Most Recent Photos | Planespotters.net
Aviation photos of aircraft registration PK-GII / PKGII shared by photographers from around the world
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H&K MR762 7.62x51 PKGII RADDLO | 642230254428 - …
Aug 27, 2021 · H&K MR762 7.62x51 PKGII RADDLO - Maximum Quantity: 2 **Mouse over image above to zoom any area, or click on image to zoom the entire image. *Please Note!! Many of our pictures are stock photo\'s provided to us by the manufacturer and do not necessarily represent the actual item being purchased. Please verify this picture accurately reflects the ...
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Roles of cyclic GMP in modulating ovarian functions ...
Jan 01, 2003 · One report indicates that PKGII expression is very low or non-existent in human ovarian tissue, although careful analysis during different phases of the ovulatory cycle was not performed (Orstavik et al., 1996). In contrast, PKGI is detectable at significant concentrations in the …
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C-natriuretic peptide: an important regulator of …
Aug 06, 2007 · In contrast, activating mutations in PKGII as well as overexpression of CNP result in significant skeletal overgrowth in mice, demonstrating the positive role of CNP signaling in regulation of mammalian chondrocyte proliferation and cartilage matrix production. This is further supported by the existence of a human dwarfism, acromesomelic ...
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What is the role of pkg2 in the colon?
Downregulation of PKG2 was associated with malignant and benign breast tumors. The work presented here demonstrates a novel antiproliferative and prodifferentiation role for PKG2 in the colon. The results suggest that PKGII inhibits EGF-induced MAPK/JNK-mediated signal transduction and further confirmed that PKGII can block the activation of EGFR.
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How does pkg2 inhibit egfinduced activation of HER2?
PKG II inhibits EGFinduced activation of HER2 through binding with and causing threonine 686 phosphorylation of this oncogenic protein. The C-terminal cyclic nucleotide binding (CNB-B) domain of cGMP-dependent protein kinase II binds cGMP with higher affinity and selectivity when compared with its N-terminal CNB (CNB-A) domain.
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What does the resultprkg2 protein kinase gene encode?
This gene encodes a protein that belongs to the serine/threonine protein kinase family of proteins. The encoded protein binds to and inhibits the activation of several receptor tyrosine kinases. The membrane-bound protein is a regulator of intestinal secretion, bone growth and renin secretion.
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