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Pathology Outlines - Stains & CD markers
Jul 27, 2022 · GI. Colon / appendix: CDX2 CK20 CMV chromogranin colon cancer biomarker testing (including MSI / Lynch) HER2 colon Ki67 MLH1 MSH1 MSH2 MSH6 PMS2 SATB2 synaptophysin. Esophagus: CMV GMS HER2 stomach GEJ p63. Liver: arginase1 BSEP (pending) CMV HepPar1 iron MDR3 (pending) PAS reticulin serum amyloid A / SAA trichrome.
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Pathology Outlines - INSM1
Jun 24, 2022 · Prognostic factors. High expression of INSM1 is associated with increased progression free survival and chemosensitivity in small cell lung carcinoma ( Oncotarget 2017;8:73745 ) Higher expression in midgut gastrointestinal neuroendocrine carcinomas with metastases compared to those not yet metastasized ( Am J Clin Pathol 2015;144:579 )
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Pathology Outlines - SSTR2A
Apr 21, 2022 · Pathophysiology. Transmembrane G protein coupled receptor widely distributed in normal human tissues. Mediates antisecretory effects of somatostatin by inhibiting high voltage activated calcium channels ( FEBS Lett 1994;355:117 ) Mediates antiproliferative effect in tumors via direct and indirect mechanisms. Direct mechanisms include promotion ...
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Pathology Outlines - CA125
Jun 23, 2021 · Stains & molecular markers - CA125. (1) For ovarian carcinomas, use serum levels to follow response to treatment and predict prognosis (Ann Oncol 2008;19:327) (2) In UK, recommended to use serum levels to screen women with symptoms of ovarian cancer (National Health Service Press Release) (3) Serial measurements may be more specific for ovarian cancer
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Pathology Outlines - WT1
Nov 22, 2021 · Essential features. Interpretation is based on staining pattern and antibody used. Staining patterns: nuclear and cytoplasmic. Antibodies: against N and C terminal. Expressed in a broad spectrum of tumors, including malignant mesothelioma, ovarian serous epithelial tumors and sex cord stromal tumors, astrocytoma, glioblastoma, benign and malignant …
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Pathology Outlines - TdT
May 24, 2022 · Pathophysiology Catalyzes addition of deoxynucleotides to the 3'-OH end of DNA primers Adds nontemplated nucleotides at the junctions of V (D)J gene segments ( Chembiochem 2019;20:860 ) Contributes to immunoglobulin and T cell receptor diversity Interpretation Nuclear stain Uses by pathologists
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Pathology Outlines - Napsin A
Jun 06, 2022 · Definition / general. A novel aspartic proteinase of the pepsin family involved in the maturation of surfactant protein B. Found primarily in lung and kidney. Lack of Napsin A expression in tumor cells may be poor prognostic marker in pulmonary adenocarcinoma ( Lung Cancer 2012;77:156)
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Pathology Outlines - BAP1
Pathophysiology. Ubiquitin tag promotes breakdown of certain proteins. BAP1 removes ubiquitin tags, thereby inhibiting protein breakdown, which affects diverse cellular processes. BAP1 is thought to help inhibit cell proliferation and promote apoptosis of damaged cells. BAP1 protein is normally localized in the cell nucleus due to the presence ...
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Stains - Libre Pathology
2 rows · Ziehl-Neelson stain - used to look for Mycobacterium tuberculosis. Fite stain - used to look for ...
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