Keyword Analysis & Research: genetics of multiple sclerosis
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Genetics of Multiple Sclerosis: An Overview and New Directions
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027932/
WebDuring the past few years, genome-wide association studies (GWAS) have revolutionized the genetics of multiple sclerosis, uncovering more than 200 implicated genetic loci. Here, we describe these main findings and discuss the new avenues that these discoveries lay …
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The Genetics of Multiple Sclerosis - Multiple Sclerosis - NCBI Bookshelf
https://www.ncbi.nlm.nih.gov/books/NBK470155/
WebNov 27, 2017 · Multiple sclerosis (MS) is an autoimmune disease of the central nervous system, characterized by focal inflammation, demyelination, and axonal injury. The etiology of MS is still uncertain, but the most updated working model for disease pathogenesis proposes the interplay between genetic and environmental factors as necessary for MS manifestation.
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The genetics of multiple sclerosis: An up-to-date review
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5967887/
WebAbstract. Multiple sclerosis (MS) is a prevalent inflammatory disease of the central nervous system that often leads to disability in young adults. Treatment options are limited and often only partly effective. The disease is likely caused by a complex interaction between multiple genes and environmental factors, leading to inflammatory ...
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Multiple sclerosis: MedlinePlus Genetics
https://medlineplus.gov/genetics/condition/multiple-sclerosis/
WebAlthough the cause of multiple sclerosis is unknown, variations in dozens of genes are thought to be involved in multiple sclerosis risk. Changes in the HLA-DRB1 gene are the strongest genetic risk factors for developing multiple sclerosis.
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Your Genes and Multiple Sclerosis (MS) - WebMD
https://www.webmd.com/multiple-sclerosis/your-genes-multiple-sclerosis
WebApr 19, 2022 · Scientists know of more than 200 genes or genetic variations (mutations) that may contribute to MS. A lot of these genes help build and maintain the immune system. Some of them are linked to...
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What Causes MS? | National MS Society
https://www.nationalmssociety.org/What-is-MS/What-Causes-MS
WebGenetics (understanding the genes that may not be functioning correctly in people who develop MS) Infectious agents (such as viruses) Understanding what causes MS will speed up the process of finding more effective ways to treat it and — ultimately — cure it. Ideally, we will find a way to prevent MS from occurring in the first place.
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Multiple sclerosis - Symptoms and causes - Mayo Clinic
https://www.mayoclinic.org/diseases-conditions/multiple-sclerosis/symptoms-causes/syc-20350269
WebDec 24, 2022 · Multiple sclerosis (MS) is a potentially disabling disease of the brain and spinal cord (central nervous system). In MS , the immune system attacks the protective sheath (myelin) that covers nerve fibers and causes communication problems between your brain and the rest of your body.
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The genetic architecture of multiple sclerosis | Nature Medicine
https://www.nature.com/articles/s41591-019-0656-3
WebNov 7, 2019 · They found a large number of new genetic loci associated with MS, including the first variant identified on the X chromosome and an enrichment of MS genes in both the innate and adaptive immune...
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The genetics of multiple sclerosis: SNPs to pathways to ... - Nature
https://www.nature.com/articles/nrg2395
WebJun 10, 2008 · The genetic component of MS is reflected in the co-occurrence of cases within families and the high prevalence in some ethnic populations (particularly those of northern European origin) compared...
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About Multiple Sclerosis (MS) | National MS Society
https://www.nationalmssociety.org/For-Professionals/Clinical-Care/About-MS/Interaction-of-Genetics-and-the-Environment/Genetics
WebThe International MS Genetics Consortium (IMSGC) has confirmed that MS risk is governed by 233 human genomic variations in the largest MS genetics study to date ( Patsopoulos et al., 2019 ).
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