Keyword Analysis & Research: gain of function
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Gain-of-function research - Wikipedia
https://en.wikipedia.org/wiki/Gain-of-function_research
WebGain-of-function research ( GoF research or GoFR) is medical research that genetically alters an organism in a way that may enhance the biological functions of gene products. This may include an altered pathogenesis, transmissibility, or host range, i.e., the types of hosts that a microorganism can infect.
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What is 'gain-of-function' and why does it matter in the search for
https://phys.org/news/2021-06-gain-of-function-sars-cov-.html
WebJun 21, 2021 · What does gain of function mean? Any organism can acquire a new ability or property, or "gain" a "function." This can happen through natural selection or a researcher's...
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Gain-of-Function Research: Background and Alternatives
https://www.ncbi.nlm.nih.gov/books/NBK285579/
WebApr 13, 2015 · TYPES OF GAIN-OF-FUNCTION (GOF) RESEARCH. Subbarao explained that routine virological methods involve experiments that aim to produce a gain of a desired function, such as higher yields for vaccine strains, but often also lead to loss of function, such as loss of the ability for a virus to replicate well, as a consequence.
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Loss-of-function, gain-of-function and dominant-negative ... - Nature
https://www.nature.com/articles/s41467-022-31686-6
WebPublished: 06 July 2022. Loss-of-function, gain-of-function and dominant-negative mutations have profoundly different effects on protein structure. Lukas Gerasimavicius, Benjamin J....
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Gain-of-Function Mutations: An Emerging Advantage for Cancer …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6944532/
WebElucidating the functional pathways altered by loss-of-function (LOF) or gain-of-function (GOF) mutations will be crucial for prioritizing cancer-causing variants and their resultant therapeutic liabilities.
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What is Gain-of-Function Research? - News-Medical.net
https://www.news-medical.net/health/What-is-Gain-of-Function-Research.aspx
WebSep 4, 2022 · Gain-of-function research (GOFR) refers to the serial passaging of microorganisms to increase their transmissibility, virulence, immunogenicity, and host …
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Gain-of-Function Research and the Relevance to Clinical Practice
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7107371/
WebMay 5, 2016 · Gain-of-function (GOF) research typically involves mutations that confer altered functionality of a protein or other molecule. These types of mutations have been used as powerful tools to understand basic bacterial …
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Gain-of-function research is more than just tweaking risky viruses …
https://theconversation.com/gain-of-function-research-is-more-than-just-tweaking-risky-viruses-its-a-routine-and-essential-tool-in-all-biology-research-202084
WebMay 8, 2023 · What is gain of function? To study how a living thing operates, scientists can change a specific part of it and then observe the effects. These changes sometimes result in the organism’s gaining...
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Gain-of-function experiments: time for a real debate - Nature
https://www.nature.com/articles/nrmicro3405
WebPublished: 08 December 2014. Gain-of-function experiments: time for a real debate. W. Paul Duprex, Ron A. M. Fouchier, Michael J. Imperiale, Marc Lipsitch & David A. Relman. Nature Reviews...
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The shifting sands of ‘gain-of-function’ research - Nature
https://www.nature.com/articles/d41586-021-02903-x
Web27 October 2021. The shifting sands of ‘gain-of-function’ research. The mystery of COVID’s origins has reignited a contentious debate about potentially risky studies and the fuzzy terminology...
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